America is a vast country with diverse cities full of culture, cuisine, history, and entertainment. From the bright lights of New York to the beaches of Los Angeles, urban centers across the states each have their own unique vibe. If you want to experience the energy of the USA, a city-hopping trip allows you to sample some of the country’s most iconic metropolises. With so many affordable flights between cities these days, it’s easier than ever to crisscross the country.

New York City

The first stop on a quintessential US city tour should be New York City. From its world-famous skyline to its 24-hour energy, NYC embodies the excitement and hustle-bustle of America. Spend days getting lost in museums like the Museum of Modern Art and the Metropolitan Museum of Art. Take in panoramic views of Manhattan from the Top of the Rock observation deck and Central Park. See a Broadway show for some only-in-NYC entertainment. Foodies can dine on authentic New York-style pizza and bagels. With so many cheap flights to New York from across the country, the Big Apple is very accessible for travelers wanting to kick off their city-hopping itinerary.

New Orleans, Louisiana

For a complete change of pace, head south to New Orleans. Synonymous with Mardi Gras and jazz music, NOLA has a funky vibe you won’t find anywhere else in the US. The historic French Quarter is made for wandering, with vibrant buildings, galleries, restaurants, and of course, Bourbon Street. Indulge in some authentic Creole and Cajun cuisine while you’re there. Tour the Garden District to see some classic Southern architecture. And no trip to New Orleans is complete without trying beignets and cafe au lait at the famous Cafe Du Monde.

Chicago, Illinois

Continue inland to the Midwest and spend some time in Chicago, Illinois. The Windy City boasts world-class museums, including the Art Institute of Chicago, architectural boat tours along the Chicago River, and of course, deep-dish pizza. Visit numerous city neighborhoods, each with its own flavor, from Chinatown to Little Italy. Be sure to snap a pic in front of the giant Bean sculpture in Millennium Park and take in a view of the Chicago skyline from the Willis Tower Skydeck. If you visit in the summer, catch some music at a blues or jazz festival.

Los Angeles, California

What’s a US city-hopping vacation without a visit to the sunny paradise of Los Angeles? LA is the perfect blend of coastal city meets Hollywood glamour. Spend an afternoon on Venice Beach taking in street performers and funky shops, or breathe in the ocean air during a beachfront bike ride along Santa Monica. Do some star-spotting and sightseeing in neighborhoods like Beverly Hills and Hollywood. Hike up to the Hollywood sign or get a behind-the-scenes look at movie magic at a studio tour. And don’t miss out on incredible multi-cultural cuisine, from Korean BBQ to Oaxacan tacos.

San Francisco, California

Cap off your urban adventure in Northern California with a stay in eclectic San Francisco. With its hilly terrain and charming Victorian architecture, SF has a totally distinctive feel. Take one of the iconic cable cars up and down SF’s steep hills, snap photos of the Painted Ladies row houses, and wander through Chinatown and Fisherman’s Wharf. Be sure to escape to nature and take in views of the city and the Bay from a hike over the Golden Gate Bridge or a day trip to Muir Woods. Sample local favorites like clam chowder sourdough bread, Ghirardelli chocolate, and California wine country offerings. Your multi-city journey through America’s most dynamic metropolises ends on a high note in cultural SF.

With vibrant performing arts, museums, ethnic enclaves, iconic landmarks, and amazing food and drink, America’s cities offer endless opportunities for exploration and one-of-a-kind travel experiences. So, grab your suitcase and start booking those affordable domestic flights to crisscross the country. This USA city-hopping itinerary takes you to five urban gems which each showcase distinct pieces of American culture.